A Comparative Evaluation of the Sensitivity of Seven Anti‐Hepatitis C Virus Screening Tests

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Abstract
The sensitivity of the most recent generation of anti-hepatitis C virus (anti-HCV) screening tests from seven manufacturers was evaluated with a common panel of 530 specimens from 320 HCV-infected subjects. This panel included 221 samples from 57 seroconverters (53 pre-sero conversion negative specimens and 168 positive samples) and 309 selected specimens from 263 other HCV-infected patients of which 19% exhibited NS3 or core reactivity alone with the presence of HCV-RNA assessed by PCR. None of the seven screening tests detected all infectious and antibody-positive specimens. However, important differences were observed between these assays in the number of false-negative results, which seemed mainly due to nonreactivity of antibody to the NS3 antigen.

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