Supraclinoid intracarotid chemotherapy using a flow-directed soft-tipped catheter.

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Abstract
In an attempt to avoid toxic reactions of the eye [as demonstrated by the changes on a electroretinogram] as a complication of internal carotid arterial infusion of cisplatin, carmustine, or a combination of both for the treatment of brain tumors, a new Gore-Tex/Teflon coaxial catheter system has been used for supraclinoid placement. Catheter placement was successful in 14 of 16 attempts in 8 patients. Two patients experienced eye pain and conjunctivitis, a result of the chemotherapeutic agent leaking through the Gore-Tex portion of the catheter at the infusion rate of 170 ml/h. No complications were noted as long as the infusion rate was maintained at 125 ml/h or lower.