Interaction of halogenacetates and SH compounds

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Abstract
Neutral solutions of Na iodoacetate and glutathione reacted to give iodine and a thio-ether; the behavior of bromoacetate was similar but less vigorous; that of chloroacetate was much less so. A similar reaction occurred with cysteine, and the thio-ether was isolated in the the pure state. The iodo-acetate-inhibition of glyoxalase activity was reversed completely by the addition of glutathione to the inactivated extract. The conc. of iodoacetate necessary to inhibit glyoxalase preparations depended on the method of preparation of the extracts; being equivalent to the content of added glutathione for dialyzed preparations.

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