Synthesis of potential hypolipidemic agents. Reaction of substituted phenyl 2,3-epoxypropyl ethers with adenine, uracil, and thymine

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Abstract
Adenine derivatives (3) were active hypolipidemic agents at 10 mg/kg per day. The most active compound was 9-(p-chlorophenoxy-2-hydroxypropyl)adenine which significantly lowered serum triglyceride and cholesterol content in male Sprague-Dawley rats and inhibited hepatic phosphatidate phosphohydrolase activity in vitro. The synthesis of these agents involved reacting adenine, uracil and thymine with a series of substituted phenyl 2,3-epoxypropyl ethers.