Delayed Haemolytic Transfusion Reactions due to Anti‐C

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Abstract
In 5 patients of phenotype ccDEe or ccDEE, the transfusion of 2-14 U [units] of C-positive blood was followed 5-9 days later by hemoglobinuria lasting 2-4 days. Anti-C was the only antibody present in all 5 cases but was always of low titer; with CC cells the maximum titer recorded with the indirect antiglobulin test was 8 and with the agglutination of enzyme-treated cells, 128. The discordance between the weakness of the antibody in vivo and the amount of Hb released intravascularly is surprising but may be related to the type of Ig[immunoglobulin]G molecule of which anti-C is composed.