Reproducibility of Time and Frequency Domain Analysis of Heart Rate Variability in Patients with Chronic Stable Angina

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Abstract
Before heart rate variability (HRV) can be used to investigate the effects of drugs or other clinical interventions in chronic stable angina, it is important to establish the stability and reproducibility of HRV indices over time. HRV analysis was performed on two consecutive 24-hour ambulatory ECG recordings in 19 patients with chronic stable angina. Time-domain analysis included average heart rate, variance, SDNN, SDANN5, ASDNN5 and PNN50. The power spectral analysis was computed using fast Fourier transformation for the total power (0.003 and 0.40 Hz), low frequency (0.04-0.15 Hz), and high frequency (0.15-0.40 Hz) bands. No statistically significant differences in the time or frequency domains were found between the two ambulatory ECG recordings. HRV indices in the time and frequency domains are consistent and reproducible in patients with chronic stable angina. Thus, cardiac autonomic tone can be evaluated using HRV analyses, and any significant changes that occur after medical therapy or other clinical interventions can be ascribed to the intervention rather than the lability of cardiac autonomic tone.