Thrombotic Thrombocytopenic Purpura
Top Cited Papers
- 4 May 2006
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 354 (18) , 1927-1935
- https://doi.org/10.1056/nejmcp053024
Abstract
A 40-year-old obese black woman has had weakness and epigastric pain for several weeks and diarrhea and vomiting for four days. She does not appear acutely ill; the physical examination is normal except for abdominal tenderness. Her hematocrit is 25 percent. The platelet count is 10,000 per cubic millimeter. The peripheral-blood smear shows occasional fragmented and polychromatophilic red cells. The serum creatinine level is 1.1 mg per deciliter (97.2 μmol per liter), bilirubin 2.5 mg per deciliter (42.8 μmol per liter), and lactate dehydrogenase 722 U per liter (normal, <250). How should this case be managed?Keywords
This publication has 46 references indexed in Scilit:
- Rituximab therapy for thrombotic thrombocytopenic purpura: A proposed study of the Transfusion Medicine/Hemostasis Clinical Trials Network with a systematic review of rituximab therapy for immune‐mediated disordersJournal of Clinical Apheresis, 2006
- The pathogenicity of von Willebrand factor in thrombotic thrombocytopenic purpura: reconsideration of treatment with cryopoor plasmaTransfusion, 2006
- Complications of plasma exchange in patients treated for clinically suspected thrombotic thrombocytopenic purpura‐hemolytic uremic syndromeTransfusion, 2005
- Thrombotic thrombocytopenic purpura and its diagnosisJournal of Thrombosis and Haemostasis, 2005
- Effect of plasma exchange on plasma ADAMTS13 metalloprotease activity, inhibitor level, and clinical outcome in patients with idiopathic and nonidiopathic thrombotic thrombocytopenic purpuraBlood, 2004
- Morphologic diagnosis of thrombotic thrombocytopenic purpuraAmerican Journal of Hematology, 2003
- Therapeutic apheresis: a summary of current indication categories endorsed by the AABB and the American Society for ApheresisTransfusion, 2003
- Aetiology and pathogenesis of thrombotic thrombocytopenic purpura and haemolytic uraemic syndrome: the role of von Willebrand factor-cleaving proteaseBest Practice & Research Clinical Haematology, 2001
- Cryosupernatant as replacement fluid for plasma exchange in thrombotic thrombocytopenic purpuraBritish Journal of Haematology, 1996
- Thrombotic thrombocytopenic purpura: outcome in 24 patients with renal impairment treated with plasma exchangeTransfusion, 1992