Renal transport of uric acid in the guinea pig

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Abstract
The stop-flow procedure was adapted to the guinea pig and 49 technically satisfactory experiments were performed with mild hyperurlcemla induced by urate infusions. Animals varied widely with control urate-to-Inulln clearance ratios ranging from 0.6 to 4.0, indicating that uric acid is normally either reabsorbed, or secreted, or possibly both. The stop-flow pattern revealed no distal permeability to urate; proximal secretion was common. Drugs were examined with each animal as its own control. Probenecld strongly inhibited proximal urate secretion making proximal reabsorption apparent. Pyrazinoic acid slightly inhibited secretion. No statistically significant effect could be attributed to ouabain, lactic acid, or chlorothlazlde. The uptake of urate by slices of kidney cortex was essentially the same for the guinea pig as for the rabbit. The results are interpreted as showing that in the guinea pig, as in other laboratory mammals, there is bidirectional transport of urate in the proximal segment. The marked species variation in drug response remains unexplained. Pyrazinoic acid is secreted by the guinea pig, reabsorbed by the rabbit.

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