The effect of flow on displacement of proteins at interfaces in plasma

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Abstract
The serial displacement of plasma proteins is a well‐established phenomenon which occurs in the first moments of contact between blood and an artifical surface. Components of the phenomenon have been elucidated as spatial and temporal patterns by slowing the process through the use of diluted plasma. This paper reports preliminary efforts towards showing that the spatial and temporal patterns of thrombogenesis from whole blood may be related to the phenomenon in systems where separated flows are present. Protein deposition revealed through subsequent adhesion of metal oxide particles shows a slowly evolving pattern in the region distal to a “downstep”; over which a shear flow of protein solution was maintained.