IMMUNE SUPPRESSION OF ERYTHROPOIESIS IN TRANSIENT ERYTHROBLASTOPENIA OF CHILDHOOD

  • 1 January 1979
    • journal article
    • research article
    • Vol. 54  (3) , 742-746
Abstract
Serum and Ig[immunoglobulin]G from 4 children with transient erythroblastopenia of childhood (TEC) was tested to see what effect it would have on development of erythroid colonies from bone marrow mononuclear cells. Serum and IgG specimens obtained at the time of diagnosis uniformly suppressed erythroic colony development from CFU-E [erythroid colony-forming units]. Washed bone marrow mononuclear cells from a child with TEC failed to grow in the presence of his own serum, but grew normally in the presence of isologous serum. Serum specimens obtained from patients after recovery from TEC had no effect on erythroid colony development. The anemia of TEC appears to be due to transient immune suppression of erythroid colony development.

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