VITAMIN A POTENCY OF RETINAL TISSUE

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Abstract
Of 33 rats kept on vitamin A-free basal diet, 4 were given daily supplements of 20 mgm. pig''s retina, 4 received 100 mgm. butterfat, and 3 received no supplement; the remaining 22 received no supplementary food until signs of ophthalmia appeared; then 6 received each 50 mgm. retina, 6, 30 mgm., 5, 20 mgm., 4, 50 mgm. choroid, and 1, 100 mgm. butterfat. In the 6 rats given 50 mgm. and in the 6 given 30 mgm. of dried retina daily after the development of ocular symptoms, the eyes were restored to normal appearance in 3-7 days and in 5-11 days respectively; growth was normal during life, and nutrition found good at necropsy. Of the 5 rats receiving 20 mgm. retina daily, in 4 the ocular symptoms cleared up, but slowly. Growth was resumed, also slowly. Choroid induced no improvement of ocular symptoms and very slow growth; leg weakness or posterior paralysis occurred in the 4 animals of this group.

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