Self reported non-insulin dependent diabetes, family history, and risk of prevalent colorectal cancer: population based, cross sectional study

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Abstract
Participants for this analysis were recruited between 1993 and 1997 as part of the East Anglian component of the European Prospective Investigation into Cancer (EPIC–Norfolk). The detailed design of the study has been previously described.6 Briefly, all men and women aged 45–74 years identified from lists of participating general practices were invited to join the study. The participants completed a detailed health and lifestyle questionnaire, which included questions on smoking (current, former, and never), height, weight, level of education (further education), past history of disease, age of diagnosis, and family history of disease. Prevalent colorectal cancer (International Classification of Diseases,7 ICD-9 153.0–153.9, 154.0 and 154) was ascertained by matching participants to the East Anglian Cancer Registry. For these analyses, we excluded all participants with prevalent cancer other than colorectal cancer or non-melanoma skin cancer, those with diabetes diagnosed before age 30 years as they were more likely to have insulin-dependent diabetes, and all diabetics who did not report their age of diagnosis. Unconditional multivariate logistic regression was used to measure the association between NIDDM, family history and risk of prevalent colorectal cancer. Maximum likelihood methods were used to estimate odds ratios and 95% confidence intervals.