MECHANISM FOR THE DILUENT RESPONSE IN ASTHMA

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 43  (6) , 341-344
Abstract
To investigate the mechanism underlying the airway response to diluent challenge, 3 adult [allergic] asthmatic patients who were known to be reactive to inhaled diluent were studied. Airway response as measured by conventional pulmonary function testing was measured under the conditions of time, inhalation of room air, diluent and placebo. Two patients responded to time or to room air, suggesting that the response was not due to the phenol-buffered diluent. The 3rd subject reacted primarily to the diluent and not to time, room air or normal saline. Two of the 3 patients were placebo responders.