A Rapid and Sensitive Method for Determination of Trimetrexate from Biological Fluids
- 1 January 1985
- journal article
- research article
- Published by Taylor & Francis in Journal of Liquid Chromatography
- Vol. 8 (1) , 125-134
- https://doi.org/10.1080/01483918508067067
Abstract
Trimetrexate (2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyllquinazoline), (Fig. 1), a potent inhibitor of dihydrofolate reductase (DHFR), has demonstrated antitumor activity against murine and human cell lines both in vitro and against a spectrum of murine tumors in vivo (1,Z).Keywords
This publication has 2 references indexed in Scilit:
- Enzymatic assays for 2, 4-diamino-5-methyl-6-[(3, 4, 5-trimethoxyanilino)methyl]quinazoline, a promising new “nonclassical” antifolateJournal of Pharmaceutical Sciences, 1981
- 2,4-Diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline (TMQ), a potent non-classical folate antagonist inhibitor—IBiochemical Pharmacology, 1979