Histaminausscheidung nach Belastung mit Histidin

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Abstract
Guinea pigs weighing 200-500 g. were given 5 ml. H2O/100 g. body wt. by stomach tube and then injected with 200-400 mg. histidine monohydrochloride (neutralized with NaOH) intramusc. The histamine activity of the excreted urine was detd. by its effect on isolated guinea pig intestine immersed in Tyrode''s soln. and on the intestines and blood pressure of narcotized cats. The urine contained a blood pressure lowering and intestine stimulating substance which was assumed to be histamine. As is true for histamine, the effect of this substance on the intestines was neutralized with histidine, cysteine and arginine. After inj. of 400 mg. histidine monohydrochloride, a guinea pig weighing 450 g. excreted in 6 hrs. 20 ml. of urine containing 205 7 histamine. Increasing the amt. of histidine administered increased the amt. of histamine excreted. Contrary to the results of others, there was no storage of histamine in the lungs of 24 guinea pigs after inj. with histidine. The excretion of histamine in the urine after parenteral adm. of histidine showed that the amine was not formed by bacteria but in intermediary metabolism, probably by histidine decarboxylase in the kidneys.

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