Ethanol Feeding and Choline Deficiency as Influences on Hepatic Choline Uptake

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Abstract
This study shows that rats fed a choline-deficient diet for 5 days have livers which under perfusion have an increased ability to take up exogenous choline. Choline-deficient animals fed the diet for 21 days have livers that show normal choline uptake. Animals fed ethanol for a 24-day period were shown to have livers which on perfusion took up higher quantities of choline than control livers. The results of the ethanol-feeding experiment are explained on the basis of the findings of other workers that ethanol increases the requirement for choline in the liver.

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