Probing the Limits of Electrostatic Catalysis by Uracil DNA Glycosylase Using Transition State Mimicry and Mutagenesis
Open Access
- 1 May 2002
- journal article
- Published by Elsevier
- Vol. 277 (18) , 15385-15392
- https://doi.org/10.1074/jbc.m200634200
Abstract
No abstract availableKeywords
This publication has 22 references indexed in Scilit:
- Selective Inhibition of Herpes Simplex Virus Type-1 Uracil-DNA Glycosylase by Designed Substrate AnalogsJournal of Biological Chemistry, 2000
- Raman Spectroscopy of Uracil DNA Glycosylase−DNA Complexes: Insights into DNA Damage Recognition and CatalysisBiochemistry, 2000
- Stressing-Out DNA? The Contribution of Serine−Phosphodiester Interactions in Catalysis by Uracil DNA GlycosylaseBiochemistry, 2000
- Escherichia coli Uracil DNA Glycosylase: NMR Characterization of the Short Hydrogen Bond from His187 to Uracil O2Biochemistry, 2000
- A Large Difference in the Thermodynamics of Binding of Isofagomine and 1-Deoxynojirimycin to β-GlucosidaseJournal of the American Chemical Society, 2000
- NMR Evidence for an Unusually Low N1 pKa for Uracil Bound to Uracil DNA Glycosylase: Implications for CatalysisJournal of the American Chemical Society, 2000
- Heteronuclear NMR and Crystallographic Studies of Wild-Type and H187Q Escherichia coli Uracil DNA Glycosylase: Electrophilic Catalysis of Uracil Expulsion by a Neutral Histidine 187Biochemistry, 1999
- Kinetic Mechanism of Damage Site Recognition and Uracil Flipping by Escherichia coli Uracil DNA GlycosylaseBiochemistry, 1998
- 1-Azaribofuranoside Analogues as Designed Inhibitors of Purine Nucleoside Phosphorylase. Synthesis and Biological Evaluation.Acta Chemica Scandinavica, 1998
- 4-Oxalocrotonate Tautomerase: pH Dependence of Catalysis and pKa Values of Active Site ResiduesBiochemistry, 1996