New Translocations in Chronic Granulocytic Leukaemia: t(X;22) (p22;q11) and t(15;22) (q26;q11)
- 1 February 1979
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 41 (2) , 185-191
- https://doi.org/10.1111/j.1365-2141.1979.tb05847.x
Abstract
Two cases of Ph1-positive chronic granulocytic leukemia with hitherto undescribed translocations are presented. In case 1, the deleted part of chromosome number 22q- was translocated to the short arm of the X chromosome, t(X;22)(p22;q11). Pronounced basophilia, trisomy 19 in the majority of metaphases and a partial cytogenetic normalization of the bone marrow during busulfan induced remission were additional remarkable features of this case. In case 2, a translocation t(15;22)(q26;q11) was found. In this case the disease was characterized by an increase of unusually small megakaryocytes, thrombocytosis, and an accelerated course.This publication has 8 references indexed in Scilit:
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