HPLC Retention Index Scale for Nitrogen-Bridged Compounds

Abstract
Retention indices of some nitrogen-bridged compounds having pharmacological activity have been determined. A retention index scale based on the relative retention of a homologous series of C3-C23 2-keto alkanes has been worked out. Linear relationships were found between RI and logP, allowing a prediction of retention indices. The relationships between the structures and the retention indices of these compounds have been interpreted.