Effect of Glucagon on Glucose Output from Bivascularly Perfused Rat Liver

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Abstract
Glucose output was investigated in bivascularly perfused rat liver. Flow rate was 1 ml/min/g from hepatic artery and 2 ml/min/g from portal vein. Basal glucose output (130 ± 30 (μM/ min) from bivascularly perfused liver was significantly (p < 0.02) higher than that (80 ± 20 μM/min) from usual monovascularly perfused (3 ml/min/g from portal vein) liver. However, glucagon-induced (1 ng/ml) increment in glucose output from bivascularly perfused liver (589 ± 127 (μM/30 min) was not significantly different from that (630 ± 127 μM/30 min) of monovascularly perfused liver. These results suggest that glucagon-dependent glucose output was similar in monovascularly and bivascularly perfused rat liver, and that arterial blood supply may have some role in glycogenolysis in the perfused rat liver.

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