Influenza B virus genome: assignment of viral polypeptides to RNA segments

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Abstract
All 8 RNA segments of influenza B viruses are most likely monocistronic and code for 8 virus-specific polypeptides. A genetic map of the influenza B virus genome was established, and 6 polypeptides (P1 protein, nucleoprotein, hemagglutinin, neuraminidase, M protein and nonstructural protein) were unambiguously assigned to specific RNA segments. MW estimates of the 8 individual genes were obtained by using the glyoxal method. Each influenza B virus RNA segment probably has a greater MW than the influenza A virus RNA segment which codes for the analogous gene product.