THE PROBABLE ENDOCRINE ORIGIN OF PEPTIC ULCER

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Abstract
The consensus of opinion is that chronic ulcer in man develops from the acute ulcer, and that the acute ulcer must necessarily be preceded by an initial lesion. Once the initial lesion is formed, its further development through the various stages into the chronic ulcer is attributed to the corrosive action of the hydrochloric acid of the gastric juice. However, intrinsic causes, such as the mechanical irritation of food on the ulcerated area, and extrinsic causes, such as epigastric pressure from abnormal posture, are other agents helping to produce chronicity. The presence of hyperchlorhydria in conditions other than ulcer, and the absence of ulcer in true achylia gastrica, though occasionally lesions in the stomach may be present in the latter condition, are facts suggesting that hydrochloric acid is a secondary, though prominent, factor in effecting the beginning of an ulcer. It is not the main etiologic factor. Various theories have

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