IMMUNIZATION AGAINST ANAPLASMOSIS AND BABESIOSIS .1. EVALUATION OF IMMUNIZATION USING MINIMUM INFECTIVE DOSES UNDER LABORATORY CONDITIONS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 27  (4) , 427-437
Abstract
Stable isolates of Anaplasma marginale stored at -60.degree. C were found infective when diluted 10-fold to 10-3. Stable isolates of Babesia argentina and B. bigemina stored under the same conditions were infective when diluted 10-fold to 10-1. Intact calves inoculated with the above dilutions of the stable isolates developed moderate parasitemias and recovered from infection without treatment. There was an immune response to vaccination with the formation of specific antibodies of A. marginale, B. bigemina and B. argentina as measured by the complement fixation (CF) test. All calves were resistant to artificial challenge with lethal doses of the respective parasites.

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