Prevention of persistent cerebral smooth muscle contraction in response to whole blood.
- 1 September 1978
- journal article
- research article
- Published by Wolters Kluwer Health in Stroke
- Vol. 9 (5) , 472-477
- https://doi.org/10.1161/01.str.9.5.472
Abstract
Using an in vitro system designed to measure arterial constriction, we have demonstrated the importance of platelet function in maintaining cerebral smooth muscle contraction after whole blood injection. We tested two agents, acetyl salicylic acid (ASA) and phthalazinol, both known to interfere with platelet function. In control tests normal rabbit and monkey blood produced a reliable and persistent arterial constriction. In experimental tests blood drawn from animals premedicated with ASA and phthalazinol failed to produce a persistent contraction. These results support the hypothesis that chemicals released during platelet aggregation may be important in persistent vasospasm.This publication has 31 references indexed in Scilit:
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