Prenatal findings in a monozygotic twin pregnancy with Costello syndrome
- 12 April 2002
- journal article
- case report
- Published by Wiley in Prenatal Diagnosis
- Vol. 22 (5) , 415-417
- https://doi.org/10.1002/pd.333
Abstract
This report describes the prenatal findings in monozygotic twins with Costello syndrome. At 16 weeks one twin had 9 mm of nuchal oedema: coarctation of the aorta was diagnosed after birth. At 225/7 weeks relative macrocephaly, mild pyelectasia and moderate polyhydramnios were noted in both twins. In the following 4 weeks the polyhydramnios increased significantly without visualisation of filling of the stomach. Between 275/7 and 302/7 weeks a total of 9 l amniotic fluid was drained and at 304/7 weeks prelabor premature rupture of membranes (PPROM) occurred followed by premature labor and delivery. The neonatal period was complicated by growth retardation, deglutition problems, hypotonia, cardiac and respiratory problems. Both twins died on Day 57 because of respiratory insufficiency. Copyright © 2002 John Wiley & Sons, Ltd.Keywords
This publication has 8 references indexed in Scilit:
- Three-dimensional ultrasound evaluation of the fetal faceThe Ultrasound Review of Obstetrics and Gynecology, 2001
- Decreased Elastin Deposition and High Proliferation of Fibroblasts from Costello Syndrome Are Related to Functional Deficiency in the 67-kD Elastin-Binding ProteinAmerican Journal of Human Genetics, 2000
- Costello syndrome: report of six patients including one with an embryonal rhabdomyosarcomaEuropean Journal of Pediatrics, 2000
- Costello syndrome: Phenotype, natural history, differential diagnosis, and possible causePublished by Elsevier ,1998
- Costello syndrome.Journal of Medical Genetics, 1998
- Costello syndrome: Update on the original cases and commentaryAmerican Journal of Medical Genetics, 1996
- Elastic fiber degeneration in Costello syndromeAmerican Journal of Medical Genetics, 1996
- Genetics of the Costello syndromeAmerican Journal of Medical Genetics, 1994