DISSOCIATION OF NEUTROPHIL FUNCTIONS OF EXOCYTOSIS AND CHEMOTAXIS
- 1 January 1978
- journal article
- research article
- Vol. 92 (2) , 297-302
Abstract
The peptide Gly-His-Gly is chemotactic for human neutrophils in vitro and for rabbit neutrophils in vivo but is unable to induce lysosomal enzyme release from human neutrophils at sublytic concentrations. The failure of this chemotactic peptide to elicit lysosomal enzyme release provides evidence that interaction with a chemotactic receptor does not necessarily activate chemotaxis and exocytosis in the human neutrophil, suggesting that the presumed common pathway of exocytosis and chemotaxis may be divergent at the cell receptor and/or postreceptor level.This publication has 2 references indexed in Scilit:
- Urate crystal-induced chemotactic factor: isolation and partial characterization.Journal of Clinical Investigation, 1976
- The structure-activity relations of synthetic peptides as chemotactic factors and inducers of lysosomal secretion for neutrophils.The Journal of Experimental Medicine, 1976