Studies on a synthesis of (RS)-mevalonic acid lactone
- 1 January 1984
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 8,p. 1765-1767
- https://doi.org/10.1039/p19840001765
Abstract
Full details of a high yielding synthesis of mevalonic acid lactone (1) which is of particular value in the preparation of 3- and/or 3′-labelled compounds are described. The key step, conversion of 3-hydroxy-3-methylpentane-1,5-dioic acid (3) into 3-hydroxy-3-methylpentane-1,5-dioic anhydride (4) using acetic anhydride, has been fully investigated, and an additional method using acetyl chloride and triethylamine is described.This publication has 1 reference indexed in Scilit:
- Reinvestigation of a synthesis of (R,S)-mevalonolactoneJournal of the Chemical Society, Perkin Transactions 1, 1983