Sorbic Hydroxamic Acid, an Antifungal Agent Effective over a Wide pH Range
- 1 January 1963
- journal article
- research article
- Published by American Society for Microbiology in Applied Microbiology
- Vol. 11 (4) , 362-364
- https://doi.org/10.1128/aem.11.4.362-364.1963
Abstract
Sorbic hydroxamic acid was prepared from sorbic acid by esterification and treatment with hydroxylamine (mp 133 to 135 C, pKa 8.8). Its ultraviolet spectrum in acid solution had a single absorption maximum at 262 mμ; in alkaline solution the maximal absorption shifted to 255 mμ and significant absorption appeared at 280 to 300 mμ. At concentrations of 0.1% (w/v), sorbic hydroxamic acid prevented the growth of Aspergillus niger, Penicillium notatum, Botrytis cinerea, Cladosporium herbarum, and a Rhizopus species in grape juice over the pH range 3.6 to 9.2, although sorbic acid was not effective at pH 5.7 and above.Keywords
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