Effect of low concentrations of cyanide on QOO2 of tissue slices

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Abstract
The oxygen consumption of brain, liver, and kidney slices measured in the Warburg apparatus was not significantly depressed by concentrations of sodium cyanide of 0.2, 0.5, and 2 µg/ml. This last concentration is considered equal to that attained in the blood after an injection of 0.2 mg/kg, which produces remarkable in vivo effects described elsewhere. Therefore, the effects obtained in vivo cannot be due to the depression of tissue respiration by cyanide, but are probably caused by the stimulation of chemoreceptors. A concentration of 5 µg/ml notably reduced the QOO2 of brain slices, and 10 µg/ml reduced that of all three tissues. As reported by others, 50 µg/ml reduced the QOO2 of kidney slices by 80%. It is noteworthy that 0.2 µg/ml of NaCN produced a 40% increase (P < 0.01) in the QOO2 of liver slices but only a 5–13% increase, not statistically significant, in brain slices.

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