Enhanced Proliferation of Endogenous Virus in Chinese Hamster Cells Associated with Microtubules and the Mitotic Apparatus of the Host Cell

1 July 1979

journal article
research article
Published by Microbiology Society in Journal of General Virology

Vol. 44 (1) , 45-55
https://doi.org/10.1099/0022-1317-44-1-45

Abstract

Chinese hamster ovary cells harbor intracytoplasmic virus-like particles of type A which are closely associated with sites of microtubule formation. The enhanced proliferation of these particles and their release at the cell membrane by using 5-bromodeoxyuridine or dibutyryl cyclic AMP are reported. The extracellular mature particles are similar in morphology to retroviruses of type B. Close association of the type A virus precursors with microtubule organizing centers, i.e., kinetochores, centrioles and basal bodies, and with microtubules per se, is confirmed by studying the effects of the microtubule inhibitors colcemide and vincristine sulfate. The role of microtubules in the activation and transport of the intracytoplasmic type A particles is discussed.

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