Assessment of Neutrophil Chemotaxis and Random Migration in Children and Adults

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Abstract
Polymorphonuclear leucocyte migration was studied in 16 children and 11 normal adults, both by a filter technique and under agarose. Assays were carried out in parallel. There were no significant differences (p > 0.5) between adult controls and children’s mean neutrophil migration coefficients within methods, but highly significant differences were found between methods (p < 0.001) both in adult and children’s samples. The observed intermethod differences are shown to be the result of increased random migration under agarose in both age groups.