HYPOTHALAMO-PITUITARY ADRENOCORTICAL FUNCTION IN THE RAT AFTER TREATMENT WITH BETAMETHASONE
Open Access
- 1 February 1976
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 56 (2) , 235-239
- https://doi.org/10.1111/j.1476-5381.1976.tb07447.x
Abstract
1 Hypothalamo-pituitary-adrenocortical (HPA) activity was suppressed in rats treated with betamethasone. 2 Recovery of normal HPA function occurred after corticosteroid withdrawal. 3 Although corticotrophin release was rapidly restored to its basal rate there was a delay in the return of the normal adrenocorticotrophic response to stress and normal adrenocortical function was evident only after the plasma adrenocorticotrophic hormone had reached ‘supra-normal’ levels. 4 The physiological significance and possible clinical relevance of the results are discussed.Keywords
This publication has 20 references indexed in Scilit:
- INTERRELATIONSHIPS OF PITUITARY AND PLASMA CORTICOTROPHIN AND PLASMA CORTICOSTERONE DURING ADRENOCORTICAL REGENERATION IN THE RATJournal of Endocrinology, 1975
- INTERRELATIONSHIPS OF PITUITARY AND PLASMA CORTICOTROPHIN AND PLASMA CORTICOSTERONE IN ADRENALECTOMIZED AND STRESSED, ADRENALECTOMIZED RATSJournal of Endocrinology, 1974
- THE CYTOCHEMICASL SECTION ASSAY FOR CORTICOTROPHINClinical Endocrinology, 1974
- A SENSITIVE BIOASSAY FOR ADRENOCORTICOTROPHIC HORMONE IN HUMAN PLASMAClinical Endocrinology, 1972
- THE EFFECT OF 'TRAINING' ON THE RELEASE OF CORTICOTROPHIN IN RESPONSE TO MINOR STRESSFUL PROCEDURES IN THE RATJournal of Endocrinology, 1970
- The effect of betamethasone on circadian and stress‐induced pituitary‐adrenocortical function in the ratBritish Journal of Pharmacology, 1970
- Plasma “cortisol” response to Synacthen in patients on long-term small-dose prednisone therapy.Annals of the Rheumatic Diseases, 1968
- Pituitary adrenal function during corticosteroid withdrawal in rheumatoid arthritis.Annals of the Rheumatic Diseases, 1967
- PITUITARY-ADRENAL FUNCTION DURING CORTICOSTEROID THERAPYThe Lancet, 1963
- PITUITARY AND ADRENAL FUNCTION DURING ADMINISTRATION OF SMALL DOSES OF CORTICOSTEROIDSThe Lancet, 1961