A Plutonium contaminated wound is described together with its management. Initially, 14.2 microCi of Plutonium were present in the wound this figure being reduced to about 1.8 microCi after two excisions. During the period of assessment DTPA was administered and the effect of this is discussed. Urinary excretion data were obtained and quantitative monitoring of the lymphatic channels of the arm and the liver were attempted. Various methods of assessment of body content are discussed which indicate the amount of retained Plutonium to lie between 0.1 and 1.5 microCi. Chromosome culture from blood lymphocytes was undertaken which indicated probable preferential irradiation of these cells.