Secondary regulatory sites in rat liver cholesterol biosynthesis: Role of 5-pyrophosphomevalonate decarboxylase
- 1 March 1980
- Vol. 15 (3) , 196-199
- https://doi.org/10.1007/bf02540970
Abstract
The activity of 5-pyrophosphomevalonate decarboxylase in 43,000 g supernatant fractions from livers and kidneys of male adult rats was determined. Enzyme activity in liver is significantly increased when rats are fed a diet containing 3% cholestyramine (268% of control rats) and decreased when fed a diet containing 2% choleserol (25% of control rats). No circadian rhythm of enzyme activity is found in liver or kidneys. Variations in hepatic cholesterogenesis affect the activity of 5-pyrophosphomevalonate decarboxylase in a similar way as other enzymes involved in the biosynthesis of cholesterol.This publication has 15 references indexed in Scilit:
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