DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation
Top Cited Papers
- 31 October 2003
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 302 (5646) , 890-893
- https://doi.org/10.1126/science.1090842
Abstract
In conjunction with histone modifications, DNA methylation plays critical roles in gene silencing through chromatin remodeling. Changes in DNA methylation perturb neuronal function, and mutations in a methyl-CpG–binding protein, MeCP2, are associated with Rett syndrome. We report that increased synthesis of brain-derived neurotrophic factor (BDNF) in neurons after depolarization correlates with a decrease in CpG methylation within the regulatory region of the Bdnf gene. Moreover, increased Bdnf transcription involves dissociation of the MeCP2–histone deacetylase–mSin3A repression complex from its promoter. Our findings suggest that DNA methylation–related chromatin remodeling is important for activity-dependent gene regulation that may be critical for neural plasticity.Keywords
This publication has 29 references indexed in Scilit:
- Trans allele methylation and paramutation-like effects in miceNature Genetics, 2003
- Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signalsNature Genetics, 2003
- The Methyl-CpG-binding Protein MeCP2 Links DNA Methylation to Histone MethylationJournal of Biological Chemistry, 2003
- Corepressor-Dependent Silencing of Chromosomal Regions Encoding Neuronal GenesScience, 2002
- Epigenetic Codes for Heterochromatin Formation and SilencingCell, 2002
- Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tailsGenes & Development, 2001
- DNA methylation and chromatin modificationCurrent Opinion in Genetics & Development, 1999
- Expression of DNA methyltransferase gene in mature and immature neurons as well as proliferating cells in miceDifferentiation, 1994
- Expression of DNA methyltransferase gene in mature and immature neurons as well as proliferating cells in miceDifferentiation, 1994
- Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNACell, 1992