Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment
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- 30 April 2006
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 9 (6) , 729-731
- https://doi.org/10.1038/nn1696
Abstract
Environmental enrichment increases adult hippocampal neurogenesis and alters hippocampal-dependent behavior in rodents. To investigate a causal link between these two observations, we analyzed the effect of enrichment on spatial learning and anxiety-like behavior while blocking adult hippocampal neurogenesis. We report that environmental enrichment alters behavior in mice regardless of their hippocampal neurogenic capability, providing evidence that the newborn cells do not mediate these effects of enrichment.Keywords
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