Growth Behaviors and Mechanism of Caffeine whiskers on the Granules
Open Access
- 1 January 1976
- journal article
- research article
- Published by Pharmaceutical Society of Japan in YAKUGAKU ZASSHI
- Vol. 96 (10) , 1223-1228
- https://doi.org/10.1248/yakushi1947.96.10_1223
Abstract
Needle-like crystals of caffeine [so-called whiskers] grew on the surfaces of granules containing caffeine and some ingredients during storage. Whisker growth was promoted by ingredients in the granules such as glycyrrhizic acid, pluronic F68 and hydroxypropyl-cellulose; growth was scarecely observed on the granules free from one of these ingredients. A great effect of humidity and temperature on the susceptibility to whisker growth was recognized. Caffeine whiskers were non-proper whiskers which grew at the fiber tip, not at the bottom, from caffeine molecules in the vapor phase surrounded by a crystal lattice, on the growth face of caffeine crystals.This publication has 1 reference indexed in Scilit:
- Filamentary Growths On Metal Surfaces – “Whiskers”Corrosion, 1951