Alzheimer's associated variant ubiquitin causes inhibition of the 26S proteasome and chaperone expression
- 1 July 2003
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 86 (2) , 394-404
- https://doi.org/10.1046/j.1471-4159.2003.01844.x
Abstract
Intracellular protein inclusions in Alzheimer's disease and progressive supranuclear palsy contain UBB+1, a variant ubiquitin. UBB+1 is able block the 26S proteasome in cell lines. Proteasome inhibit...Keywords
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