Human Leukocyte Antigen Class II Alleles and Rubella‐Specific Humoral and Cell‐Mediated Immunity following Measles‐Mumps‐Rubella–II Vaccination
Open Access
- 15 February 2005
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 191 (4) , 515-519
- https://doi.org/10.1086/427558
Abstract
We examined associations between human leukocyte antigen (HLA) class II genes and both rubella-specific immunoglobulin G antibodies and lymphoproliferative responses after measles-mumps-rubella-II (MMR-II) vaccination, in a population- based sample of 346 schoolchildren. The DPB1★0301, DPB1★0401, DPB1★1301, and DPB1★1501 alleles were significantly associated with rubella vaccine-induced antibodies. Alleles suggestive of being positively associated with rubella- specific lymphoproliferative stimulation indices were DPB1★0301, DQB1★0501, DRB1★0101, and DRB1★1104. Conversely, the DPB1★0401, DPB1★1001, DPB1★1101, DQB1★0202, and DRB1★0701 alleles were negatively associated with rubella- specific lymphoproliferation. This study of HLA class II-restricted humoral and cellular immune responses to rubella provides significant insight into mechanisms of vaccine response and new vaccine development.Keywords
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