Rapid Induction of Allergic Encephalomyelitis in Rats without the Use of Mycobacteria

Abstract
Rats, in contrast to certain other species of animals reported, have a striking capacity to develop allergic encephalomyelitis within 2 to 3 weeks following one injection of spinal cord antigen combined with Freund's incomplete adjuvant—that is, adjuvant prepared without addition of killed mycobacteria.