Prevention of ischemic neuronal damage by α 1-adrenoceptor agonist (methoxamine)
- 1 November 1989
- journal article
- research article
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 80 (5) , 451-454
- https://doi.org/10.1111/j.1600-0404.1989.tb03908.x
Abstract
— The effect of methoxamine, an α 1-adrenoceptor agonist, on ischemic neuronal damage was studied in the gerbil. The animals were subjected to 5 min of ischemia by bilateral common carotid arteries occlusion. Morphological changes and calcium accumulation were evaluated in the CA1 sector of the hippocampus after 7 days of survival. The degree of ischemic neuronal damage and calcium accumulation in the methoxamine-treated groups were significantly attenuated compared with the saline-treated ischemic group. The results suggest that α 1-adrenoceptor stimulation prevents ischemic neuronal damage.Keywords
This publication has 14 references indexed in Scilit:
- Early Postischemic 45Ca Accumulation in Rat Dentate HilusJournal of Cerebral Blood Flow & Metabolism, 1988
- Neuroprotective effects of adenosineTrends in Pharmacological Sciences, 1988
- Circulating Catecholamines Modulate Ischemic Brain DamageJournal of Cerebral Blood Flow & Metabolism, 1986
- A reversible type of neuronal injury following ischemia in the gerbil hippocampus.Stroke, 1986
- Glutamate and the pathophysiology of hypoxic–ischemic brain damageAnnals of Neurology, 1986
- α‐1 Adrenoceptors are decreased in human epileptic fociAnnals of Neurology, 1986
- Lesions of the locus coeruleus system aggravate ischemic damage in the rat brainNeuroscience Letters, 1985
- Regional Accumulation of Calcium in Postischemic Rat BrainJournal of Neurochemistry, 1984
- Evaluation of monoaminergic receptors in the genetically epilepsy prone ratCellular and Molecular Life Sciences, 1984
- Delayed neuronal death in the gerbil hippocampus following ischemiaBrain Research, 1982