CD20 and CD40 mediated mitogenic responses in B‐lineage acute lymphoblastic leukaemia
- 1 April 1996
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 93 (1) , 125-130
- https://doi.org/10.1046/j.1365-2141.1996.4781011.x
Abstract
Activation of CD20, a cross‐membrane ion channel, induces cell cycle progression from G0 to G1 in B lymphocytes. Subsequent activation of CD40, a membrane receptor of the nerve growth factor receptor superfamily, transits the B cells to the S phase. CD40 may also act synergistically in combination with IL‐4 (B lymphocytes) or IL‐3/IL‐7 (B‐cell precursors). We investigated the proliferative responses of B‐lineage acute lymphoblastic leukaemia (ALL) cells to CD20/CD40 activation. In 18/56 ALL cases, CD20 activation resulted in significant increases in DNA synthesis. Similar, although more moderate, effects were seen of activation of CD40 in 10/44 cases. Responses to CD20 or CD40 activation were independent of co‐stimulation with IL‐3, IL‐4 or IL‐7, and various cocktails of the different growth stimuli did not act synergistically.Keywords
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