A list is given of 26 shortcomings mentioned repeatedly in study-section discussion of 605 research grant applications that were subsequently disapproved by vote, following the discussion. The shortcomings have to do with either (1) the copception of the research problems, or (2) the proposed route of approach toward their solution, or (3) the competencies to be mobilized toward prosecution of the research, or (4) miscellaneous other matters. The percentage frequency of applications (in the total of 605) in which a given shortcoming was found is reported for each of the 26. Certain of the items in the list are discussed briefly.