Sustained G→A hypermutation during reverse transcription of an entire human immunodeficiency virus type 1 strain Vau group O genome
Open Access
- 1 April 2002
- journal article
- Published by Microbiology Society in Journal of General Virology
- Vol. 83 (4) , 801-805
- https://doi.org/10.1099/0022-1317-83-4-801
Abstract
Two full-length human immunodeficiency virus type 1 O sequences are described, one of which was hypermutated in all regions of the genome. This indicates that the intracellular [dTTP]/[dCTP] bias conducive to G→A hypermutation may be sustained throughout the synthesis of minus-strand DNA. In turn, this suggests the possibility of mutation of host sequences.Keywords
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