Biochemical Characteristics of a Human Myeloid Leukemia Cell Differentiation Factor
- 1 February 1996
- journal article
- research article
- Published by Taylor & Francis in Preparative Biochemistry & Biotechnology
- Vol. 26 (1) , 21-30
- https://doi.org/10.1080/10826069608000047
Abstract
A human lymphocyte-derived maturation-inducing activity, which mediates the differentiation of human myeloid leukemia cells HL-60 to monocytic cells, was purified and characterized. The maturation inducer is a single polypeptide with a molecular mass of 54,300 Daltons. A PI range of 8.0–8.5 was determined along with the amino acid composition of the inducer. In cell cultures, the purified inducer mediated a growth reduction and a differentiation of leukemia cells to mature monocytes-macrophages, possessing complement receptors and phagocytic capacity.Keywords
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