SYNTHESIS OF α-N-BENZOYL-L-CANAVANINAMIDE AND ITS HYDROLYSIS BY TRYPSIN AND PAPAIN
- 1 July 1959
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Biochemistry
- Vol. 46 (7) , 945-948
- https://doi.org/10.1093/oxfordjournals.jbchem.a126987
Abstract
The procedures consist of benzoylation of L-canavanine to benzoyl-L-canavanineTmelting point 215[degree]C (decomposition), (yield 57%)", esterification to its ethyl ester hydrochloride, and hydrolysis in NH3-saturated methanol to give the product, melting point 170[degree] C (yield 38%). The compound was only slightly susceptible to tryptic digestion (1/200 of [alpha]-[image]]-benzoyl-L-argininamide) at pH 7.8, while papain was active towards both amides at pH 6 at a comparable level.Keywords
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