Relationship of Systemic Inflammatory Response Syndrome to Organ Dysfunction, Length of Stay, and Mortality in Critical Surgical Illness
Open Access
- 1 January 1999
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Surgery
- Vol. 134 (1) , 81-87
- https://doi.org/10.1001/archsurg.134.1.81
Abstract
THE SYSTEMIC inflammatory response syndrome (SIRS) is a clinical response to an inflammatory or traumatic stimulus of unspecified etiology. As defined by the American College of Chest Physicians/Society of Critical Care Medicine consensus conference in 1992, SIRS is diagnosed if 2 or more of the following criteria are met: (1) temperature greater than 38°C or less than 36°C; (2) heart rate greater than 90 beats per minute; (3) respiratory rate greater than 20/min or a PaCO2 less than 32 mm Hg; or (4) white blood cell count greater than 12.0 × 109/L or less than 4.0 × 109/L or the presence of more than 10 immature bands.1 The consensus stipulated that these changes should represent an acute alteration from baseline in the absence of other known causes for such abnormalities, such as chemotherapy-induced leukopenia. Although these diagnostic criteria were established via consensus rather than quantitative study, subsequent investigations have validated their usefulness in predicting groups of patients with an increased risk of mortality.2-4Keywords
This publication has 1 reference indexed in Scilit:
- Systemic inflammatory response syndrome (SIRS) and sepsis in surgical patientsIntensive Care Medicine, 1996