Abstract
The early development of the intervertebral disc was studied in serial sagittal sections of 5 human embryos from 3.5 to 10 mm. crown-rump length. The disc is not midsegmental but slightly cranial to the middle of the segment. It is formed from the sclero-tomic tissue that bounds the intervertebral fissure and is formed therefore by the cranial as well as the caudal half of the sclerotome. The condensation of tissue, at first limited to the caudal part of the, segment, fuses with the perichordal tube and progresses cranially without regard to the boundaries of the half-segments. It surrounds the intervertebral fissure and becomes narrower and denser while the fissure disappears. The new segmentation of the axial mesenchyme is not a simple regrouping of sclerotome-halves, but a dynamic and progressive transformation of the whole mesenchyme.

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