Polyoncogenicity and Insulinoma-Inducing Ability of BK Virus, a Human Papovavirus, in Syrian Golden Hamsters23

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Abstract
Newborn hamsters were inoculated intracerebrally with a series of purified and concentrated BK virus samples originating from a single stock of Gardner's original strain. Most (60–100%) of the hamsters developed various tumors 3–9 months later. The frequent types of tumors were ventricular tumors. (choroid plexus papillomas and ependymomas: 7–53%), malignant insulinomas (0–92%), and osteosarcomas (0–50%). The Tantigen was positive in 59 of 60 tumors tested, but the virus was rescued by the cell fusion method from only 1 of 11 cell lines derived from these tumors. The incidence of insulinomas varied greatly with the virus sample; the two samples that showed the highest incidences (47 and 92%) originated from one parental virus stock, and all the other samples with the lower incidences (0–9%) originated from another ancestral stock. These results suggest the presence of a BK virus mutant(s) differing in capacity to induce insulinoma. A functional insulinoma cell line was thus established.

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