Experiments on Prevention of the Endotoxin-Abortifacient Effect by Radiodetoxified Endotoxin Pretreatment in Rats
- 1 January 1978
- journal article
- research article
- Published by S. Karger AG in Gynecologic and Obstetric Investigation
- Vol. 9 (1) , 57-64
- https://doi.org/10.1159/000300971
Abstract
Endotoxemia has been induced in pregnant rats by intravenous injection of 1 mg Escherichia coli endotoxin which resulted in intrauterine death and abortion of fetuses in 24 h. The abortifacient effect of endotoxin was prevented in 90% by 200 µg radiodetoxified endotoxin, injected intravenously 24 h earlier. The authors suppose that the radiodetoxified endotoxin can be a good tool also in the prevention of human septic (endotoxin) shock in pregnancy.Keywords
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